Kids First Data Release Flow

Projects funded by the Kids First Program result in the generation of two broad types of data.

• Patient Phenotypic Data (diagnoses, demographics, pathology reports, radiology images...)
• Sequencing Data (whole genomes, whole exomes, transcriptomes...)

The role of the Kids First Data Resource Center is to harmonize these two types of data from two different sources into one, useable dataset. These datasets are first released to the original research groups; six months later they are released to the broader scientific community.

Files Available for Kids First Studies

For each Kids First Study, three types of sequencing files are delivered as part of our standard harmonization process.

• An alignment, the complete genome sequence, in .bam or .cram format.
• Variants within an individual genome, gVCF format.
• Germline-variants called within a set of family members genomes, in VCF format.

A detailed diagram of the Kids First DRC's harmonization workflows is to the right (double-click to enlarge).

Complete details about the Kids First deliverables and workflows can be found on the Kids First GitHub page.

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